Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis
نویسندگان
چکیده
منابع مشابه
Phospholipid transfer protein and atherosclerosis.
Genetic studies in humans and mice show that two related plasma lipid transfer proteins (cholesteryl ester transfer protein [CETP] and phospholipid transfer protein [PLTP]) have distinct roles in lipoprotein metabolism, despite their homology.1 In human homozygous CETP deficiency, HDL levels are massively elevated, and LDL levels are moderately decreased.2 While a human PLTP deficiency state ha...
متن کاملMacrophage phospholipid transfer protein deficiency and ApoE secretion: impact on mouse plasma cholesterol levels and atherosclerosis.
OBJECTIVE PLTP and apoE play important roles in lipoprotein metabolism and atherosclerosis. It is known that formation of macrophage-derived foam cells (which highly express PLTP and apoE) is the critical step in the process of atherosclerosis. We investigated the relationship between PLTP and apoE in macrophages and the atherogenic relevance in a mouse model. METHODS AND RESULTS We transplan...
متن کاملIncreased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein.
Plasma phospholipid transfer protein (PLTP) is thought to be involved in the remodeling of high density lipoproteins (HDL), which are atheroprotective. It is also involved in the metabolism of very low density lipoproteins (VLDL). Hence, PLTP is thought to be an important factor in lipoprotein metabolism and the development of atherosclerosis. We have overexpressed PLTP in mice heterozygous for...
متن کاملThe effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis.
Phospholipid transfer protein (PLTP) is a member of the lipid transfer/lipopolysaccharide binding protein gene family. Recently, the crystal structure of one of the members of the gene family, bactericidal permeability increasing protein, was solved, providing potential insights into the mechanisms of action of PLTP. These molecules contain intrinsic lipid binding sites and appear to act as car...
متن کاملPhospholipid transfer protein and atherosclerosis: genetic studies take aim at a moving target.
Phospholipid transfer protein (PLTP) is a member of the lipid transfer/lipopolysaccharide-binding protein family that first attracted attention by virtue of its functions in intravascular lipoprotein metabolism. These include its key role in mediating transfer of phospholipids from very-lowdensity lipoprotein to high-density lipoprotein (HDL) in conjunction with very-low-density lipoprotein lip...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2021
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2021.03.011